Countercurrent separation assisted identification of two mammalian steroid hormones in Vitex negundo

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Sesquiterpenoids and norterpenoids from Vitex negundo.

Chemical investigation on the seeds of Vitex negundo has afforded a new furan-containing sesquiterpenoid, negunfurol (1), a new norlabdane-type diterpenoid, negundoal (2), and two new norursane-type triterpenoids, negundonorins A (3) and B (4), together with two know compounds, 3-formyl-4,5-dimethyl-8-oxo-5H-6,7-dihydronaphtho[2,3-b]furan (5) and 3-epi-corosolic acid (6). Their structures and c...

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Antioxidant and Antiinflammatory Activity of Vitex negundo

Reactive oxygen species are implicated in various inflammatory disorders. Vitex negundo is mentioned in Ayurveda as useful in treating arthritic disorders. The present work was undertaken to evaluate the antioxidant potential and anti-inflammatory activity of the plant. The total methanol extract of the plant was standardized in terms of total polyphenols. The standardized extract in a dose of ...

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Pharmacokinetic-interaction of Vitex negundo Linn. & paracetamol.

BACKGROUND & OBJECTIVES Currently, herbal preparations are clinically used as functional food, food supplements or as add on therapy, which affects the bioavailability and also the net therapeutic potential of co-administered allopathic drugs. Therefore, it is important to assess the interaction among these two classes of drugs. Here we studied the interaction between orally-administered ethano...

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Validated HPLC method for identification and quantification of p-hydroxy benzoic acid and agnuside in Vitex negundo and Vitex trifolia

A high performance liquid chromatography coupled with photodiode array detection method was developed for the identification and quantification of p-hydroxy benzoic acid and agnuside in the extracts of Vitex negundo and Vitex trifolia. The separation was achieved using acetonitrile and O-phosphoric acid-water (0.5%, v/v) as the mobile phase in an isocratic elution mode. Mean retention times of ...

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A new labdane diterpene from Vitex negundo.

CONTEXT Vitex negundo Linn. (Verbenaceae) seeds are pepper substitute and occasionally used as a condiment for edible purposes. The seeds also find use for analgesia, sedation, rheumatism and joint inflammation in folk medicine. OBJECTIVE To isolate and characterize bioactive constituents from V. negundo seeds. MATERIALS AND METHODS The ethanol extract of V. negundo seeds was subjected to r...

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ژورنال

عنوان ژورنال: Journal of Chromatography A

سال: 2018

ISSN: 0021-9673

DOI: 10.1016/j.chroma.2018.04.033